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Diazepam is N-demethylated by CYP3A4 and 2C19 on the Energetic metabolite N-desmethyldiazepam, which is hydroxylated by CYP3A4 towards the Energetic metabolite temazepam. N-desmethyldiazepam and temazepam are each even further metabolized to oxazepam. Temazepam and oxazepam are mostly removed by glucuronidation.Check neonates subjected to diazepam

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